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No. Memantine may be used off-label to provide the same benefit for people with vascular dementia. This benefit affects thinking, the ability to carry on normal daily activities, and the severity of behaviour and mood problems. Most studies (29 in 7885 people) were in people with AD. In vascular dementia, two studies in about 750 people indicated there is probably a small benefit for thinking difficulties, behaviour and mood, and there may be less agitation for memantine compared with placebo. Cochrane Database Syst Rev. Memantine is used to treat moderate to severe dementia of the Alzheimer's type. There is evidence that the excitatory activity of L-glutamate plays a role in the pathogenesis of Alzheimer's disease and in the damage from an ischaemic stroke. [1] Most studies were well conducted, but some were not well reported and we got extra information from the drug companies. Memantine protects nerve cells by blocking the effects of too much glutamate. We examined clinical trials registries, press releases and posters of memantine manufacturers; and the web sites of the FDA, EMEA and NICE. Memantine (compared with placebo) may increase the numbers of people discontinuing treatment because of adverse events (RR 2.12, 95% CI 1.03 to 4.39). Our health evidence - how can it help you. Memantine isn’t a cholinesterase inhibitor, but it also acts on chemicals in the brain. Moderate- and low-certainty evidence from two studies in around 750 participants indicates there is probably a small clinical benefit for CF: 2.15 ADAS-Cog points (95% CI 1.05 to 3.25); there may be a small clinical benefit for BM: 0.47 NOSGER disturbing behaviour points (95% CI 0.07 to 0.87); there is probably no difference in CGR: 0.03 CIBIC+ points (95% CI -0.28 to 0.34); and there may be no difference in ADL: 0.11 NOSGER II self-care subscale points (95% CI -0.35 to 0.54) or in the numbers of people discontinuing treatment: RR 1.05 (95% CI 0.83 to 1.34). Lewy body dementia (LBD) is a progressive brain disease manifest as dementia and parkinsonism, along with psychotic and autonomic disorders. This is mainly moderate-quality evidence.  |  What is memantine? 18 What do I need to tell my doctor BEFORE I take Memantine Tablets? Memantine Versus Placebo in Parkinson’s Disease Dementia or Dementia with Lewy Bodies: The purpose of this study is to determine if MEM can provide benefits on clinical symptoms in patients with PD dementia or DLB. A more recent systemic review and meta-analysis [A177106] indicates that memantine is beneficial as a first line drug for the treatment of Alzheimer's dementia. Memantine, commonly prescribed in the United States under the brand name Namenda, is for people with moderate-to-severe Alzheimer’s disease and vascular dementia. Memantine also helps with severe dementia as well as dementia of WKS (Wernicke-Korsakoff Syndrome), but the results have not been as impressive as they are with vascular dementia. Memantine Versus Placebo in Parkinson’s Disease Dementia or Dementia with Lewy Bodies: The purpose of this study is to determine if MEM can provide benefits on clinical symptoms in patients with PD dementia or DLB. We searched ALOIS, the Cochrane Dementia and Cognitive Improvement Group's register of trials (http://www.medicine.ox.ac.uk/alois/) up to 25 March 2018. View Article: Google Scholar: PubMed/NCBI. Objectives: To determine efficacy and safety of memantine for people with Alzheimer's disease (AD), vascular (VD) and mixed dementia. There were no significant differences between memantine and placebo for the number of drop-outs and total number of adverse effects, but a significant difference in favour of placebo for the number who suffer restlessness. However, when nerve cells are damaged by Alzheimer’s disease, too much glutamate is produced. Uses of Memantine Tablets: It is used to treat dementia in people with Alzheimer's disease. We found important differences in the efficacy of memantine in mild AD compared to that in moderate-to-severe AD. memantine Dosage and Administration. NCT00630500: Efficacy and Safety of Memantine for Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB) doi: 10.1002/14651858.CD003154.pub5. Cochrane Database Syst Rev. This causes more damage to the nerve cells. High-certainty evidence from up to 14 studies in around 3700 participants consistently shows a small clinical benefit for memantine versus placebo: clinical global rating (CGR): 0.21 CIBIC+ points (95% confidence interval (CI) 0.14 to 0.30); cognitive function (CF): 3.11 Severe Impairment Battery (SIB) points (95% CI 2.42 to 3.92); performance on activities of daily living (ADL): 1.09 ADL19 points (95% CI 0.62 to 1.64); and behaviour and mood (BM): 1.84 Neuropsychiatric Inventory (NPI) points (95% CI 1.05 to 2.76). 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